#5541 EVALUATION OF PROTEIN MALNUTRITION IN CKD PATIENTS ON LOW-PROTEIN DIET

Abstract Background and Aims Low-protein diet is considered crucial in patients with chronic kidney disease to slow down function deterioration control metabolic variables such as serum phosphate, urea bicarbonate. However, low-protein may result malnutrition if do not respect nutritional prescription. Thus, the present study examined risk of protein CKD who started a diet. Method We analysed anthropometric variables, nutrient intake body composition 27 stage 4-5 (M/F 15/12; 69±15 years; 72±18 kg; BMI 27.3±7 kg/m2; creatinine 4.9±1.9 mg/dl; GFR 11±4 ml/min; 10 diabetic patients) before after 3-months (0.6 g/kg). estimated food frequency questionnaire composed 37 items administered by nutritionist also prescribed measured fat mass (FM) free-fat (FFM) appendicular skeletal muscle using bioimpedentiometry analysis (Akern, Florence). Patients having lower than 0.6 g/kg at survey was defined malnourished. Results In whole sample, 3-month decreased from 0.87±0.23 0.69±0.18 (p<0.001; Wilcoxon test). Protein positively correlated 24-h urine excretion phosphate baseline (r = 0.69, p 0.012) 3-monts 0.62, 0.02). The induced decrease weight (72±18 70±17 0.001), (27.3±7 26.7±6.8 FM (24±11 21±11 0.006), (1.68±0.33 1.52±0.32 mmol/l; 0.033) (166±53 133±42 p<0.001), whereas FFM, expressed percentage weight, significantly increased (69±9 73±8%; 0.011). Six (22%; 3 had Their that other 21 above (0.43±0.1 vs 0.77±0.12 g/kg; p<0.001). These (14±2 26±11 0.03) starting (0.64±0.06 0.94±21 0.003). slightly FFM months compared value (52±7 50±7 0.07); conversely did change (51±10 53±11 0.17), but (26±11 23±12 Conclusion conclusion, occur during low consumption proteins this Nutritional necessary identify adequately follow up on